Digest Disease Mechanism (DDM) Summit

October 5-7, 2025 

The DDM Summit occurs during UEG Week and is accessible to all in-person UEG Week participants. 

The premier platform for GI science

For the first time, in 2025, we are bringing the Digestive Disease Mechanism (DDM) Summit to UEG Week, an exceptional 3-day programme focusing on the Pathogenesis of GI tract diseases (including cancer). Led by the top experts in the field, Mathias Heikenwälder, Paco Real and Maria Sibilia, the summit provides a dedicated space for basic scientists to present their latest findings, learn about the latest breakthroughs, and establish important new connections. 

Join us in hearing cutting-edge research in artificial intelligence, spatial biology, immune evasion and metabolic reprogramming, among other topics! Featuring lectures, abstract presentations and interactive group discussions, this unparalleled event offers you a unique opportunity in the field of GI research. 

DDM Summit

Talks on cutting-edge research from top international scientists

Owen Sansom, UK - Using complex models of colorectal cancer to understand the adaptive response to new therapies  
Amaia Lujambio, USA - MASH promotes immune surveillance of antigenic tumors 
Grainne O’Kane, Ireland - Precision oncology in PDAC: A whole new world 
Robert Schwabe, USA - Hepatic stellate cells regulate hepatocyte functions and metabolism 
Jerome Cros, France - Deciphering PDAC heterogeneity and treatment response through artificial intelligence 
Laura Machesky, UK - Role of mechanosensing in pancreatic cancer cell migration and invasion 
Tuomas Tammela, USA - Functional interrogation of malignant states in pancreatic cancer 
Dieter Saur, Germany - Neutrophil-driven inflammation in PDAC progression 

Showcase your research

Don't miss your chance to participate in this exciting and transformative event by submitting your abstract for the DDM Summit. If selected, you will have the opportunity to present your findings to an international audience and get your abstract featured in the UEG Journal, Gutflix, and the online programme.

You will also receive a reduced UEG Week registration fee (€ 200) and could qualify for a travel grant (up to € 750) awarded to basic scientists aged 40 or below. 

Find out more & submit abstract


Programme Directors

Mathias Heikenwälder, Germany 
Paco Real, Spain 
Maria Sibilia, Austria 

DDM Summit Programme Management

Pilar Acedo-Nunez, United Kingdom 
Najib Ben Khalid, Germany