Research Prize

Recognising leading researchers driving breakthroughs in digestive health

UEG Research Prize Awardee 2026: Michael Sigal

Michael Sigal is Professor of Translational Gastrointestinal Oncology and Head of Luminal Gastroenterology at Charité – Universitätsmedizin Berlin, Campus Virchow Klinikum. He completed his clinical and scientific training with postdoctoral research at Charité, Stanford University, and the Max Planck Institute for Infection Biology. His work focuses on how stem cell–niche interactions, microbial signals, and regenerative plasticity drive the earliest steps of gastrointestinal cancer.

The UEG Research Prize 2026 was awarded to Michael Sigal for pioneering research redefining cancer initiation as an ecosystem-driven process. By uncovering how stromal signals shape stem cell behaviour in health and disease in the stomach and intestine, and establishing advanced human assembloid models, his work opens new avenues for interceptive, microenvironment-targeted prevention and treatment strategies.

His research, supported by the European Research Council and recognised by the UEG Rising Star Award, aims to shift clinical paradigms from late-stage treatment toward early, mechanism-based prevention of gastrointestinal diseases.

We will celebrate the UEG Research Prize Awardee 2026 at the Opening Plenary of UEG Week in Barcelona on October 18, 2026.

Sigal Michael photo
  • Past awardees
Past awardees

2025: Fotios Sampaziotis, University of Cambridge, Cambridge Stem Cell Institute
Research Project: Advancing cell therapy for ischaemic cholangiopathy towards clinical translation
Watch the recording

2024: Enrique de-Madaria, Hospital General Universitario Dr. Balmis, ISABIAL, Alicante
Research Project: "The WATERLAND study"
Watch the recording

2023: Michael Bretthauer, Oslo University Hospital
Research Project: EAGLE: "The European Alliance for Gastrointestinal Lesions in Early Stages"
Watch the recording

2022: Neil Henderson, University of Edinburgh
Research Project: "Using integrated single cell genomics and spatial transcriptomics approaches to identify the key therapeutic targets driving the progression of human NASH”
Watch the talk of Neil Henderson at UEG Week 2022.

2021: Dirk Haller, TU Munich, Germany
Research Project: “Repurposing mitochondria-protective targets for adjuvant IBD therapy”

2020: Stefan Schreiber, Kiel University, Germany
Research Project: “Therapeutic mechanisms of controlled-ileocolonic-release nicotinamide (CICR-NAM) in IBD”
Watch presentation given at UEG Week Virtual 2020

2019: Silvio Danese, Humanitas Research Hospital in Milan
Research Project: "The gut virome as a trigger for IBD: from metagenomics to pathogenesis”

2018: Cisca Wijmenga, University Medical Centre Groningen (UMCG), The Netherlands
Research Project: "A celiac mucosal barrier-on-chip model to investigate its role in initiation of celiac disease”
Watch the interview with Cisca Wijmenga.
Read more about Cisca Wijmenga and women in UEG in the UEG Journal.

2017: Jesper Lagergren, Karolinska Institutet in Stockholm, Sweden
Research Project: “The aetiology, prevention and treatment of oesophageal cancer”
Watch the interview with Jesper Lagergren.

2016: Ernst J. Kuipers, Erasmus MC University Medical Center Rotterdam, The Netherlands
Research Project: “Hidden in plain sight: the opportunities for targeted surveillance and intervention for early gastric neoplasia”

2015: Jan Tack,University of Leuven, Belgium
Research Project: “Role of nutrients and tastants in determining the gastric accommodation (GA) reflex and the control of meal volume tolerance in health and disease"

2014: Rebecca Fitzgerald, Medical Research Council, Cancer Cell Unit, and Honorary Consultant in Gastroenterology at Addenbrooke's Hospital, Cambridge (UK), NIHR Research Professor
Research Project: "Combination of quantifiable genomic assays with a patient friendly non-endoscopic cell retrieval device called Cytosponge™ for management of patients with Barrett’s oesophagus"

2013: Ian Tomlinson, Welcome Trust Centre for Human Genetics, Oxford, United Kingdom
Research Project: "The roles of bone morphogenetic protein pathway genes in the normal and neoplastic intestines"

2012: Ludvig M. Sollid, University of Oslo and Oslo University Hospital, Norway
Research Project: “Antibody Response in Coeliac Disease”

2011: Pierre-Alain Clavien, University Hospital, Zurich, Switzerland
Research Project: “Liver regeneration – extending the potential of the liver after major surgery”

2010: Hans Clevers, Hubrecht Institute, Utrecht, The Netherlands
Research Project: “Develop techniques for ex vivo expansion and transplantation of stem cells from the human intestinal tract"

2009: Jean Frédéric Colombel, Hopital Claude Huriez, Lille,France
Research Project:"ORIGIN: Observing Relatives, Immunity, Genetics and the mIcrobiome before the onset of Crohn’s disease"

2008: Markus Neurath, University of Mainz, Germany
Research Project:"Molecular imaging of the intestinal immune system in IBD"


UEG Research Prize

Each year, UEG awards €50,000 for excellence in basic, translational or clinical research.

The prize supports the development of a future scientific research project, helping to advance it from an early stage towards successful completion. The UEG Research Prize recognises active, established senior researchers whose work has the potential to significantly impact digestive health.
 
Applications for the UEG Research Prize 2026 are closed. 
The next call for applications is expected to open by mid-October 2026 at the latest. 

Target group

The UEG Research Prize is aimed at active, established senior researchers whose scientific work makes a crucial contribution to digestive health and whose proposed study will significantly advance their career.

Eligible applicants should:

  • Lead a substantial research group, with work carried out mainly in Europe.
  • Focus on areas of research that typically face greater challenges in securing funding.
  • Have a proven record of peer-reviewed grants from internationally recognised research councils, charities, or industry partners.
  • Commit to completing the proposed research within the agreed timeframe.
  • Have been either
    • listed as (co-)author of a UEG Week abstract submitted in the past three years,
    • or recognised as a UEG Rising Star within the last five years.

Please note:

  • Departments that have received a UEG Research Prize in the past five years are not eligible.
  • The prize may be awarded to the same recipient only once.
  • The prize is open to all UEG Associates, and we encourage applications from all fields of digestive health.

Contact
Research EU Project Management
Henrich Hipca