THE SOLUTE TRANSPORTER OCTN1/SLC22A4 AFFECTS DISEASE SEVERITY AND RESPONSE TO INFLIXIMAB IN EXPERIMENTAL COLITIS: ROLE OF GUT MICROBIOTA AND IMMUNE MODULATION

Letizia Masi  ¹     Federica Del Chierico  ²     Valentina Petito  ²     Valerio Baldelli  ²     Pierluigi Puca  ³     Maria Cristina Giustiniani  ⁴     Marco Fidaleo  ⁵     Ivana Palucci  ^{6, 7}     Loris Riccardo Lopetuso  ^{1, 8}     Maria Emiliana Caristo  ⁹     Lorenza Putignani  ¹⁰     Antonio Gasbarrini  ^{1, 11}     Giovambattista Pani  ¹¹     Franco Scaldaferri  ^{1, 11    
1} Department of Medical and Surgical Sciences, IBD Unit, Center for Diseases of Digestive System (CeMAD), Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
² Immunology, Rheumatology and Infectious Diseases Research Area, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy
³ Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy
⁴ Institute of Pathological Anatomy, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy
⁵ Department of Biology and Biotechnologies Charles Darwin, Università La Sapienza, Rome, Italy
⁶ Department of Basic Biotechnological Sciences, Intensive and Perioperative Clinics, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy
⁷ Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
⁸ Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chi
⁹ Cen.Ri.S Policlinico Gemelli UNICATT, Rome, Italy
¹⁰ Unit of Microbiology and Diagnostic Immunology, Unit of Microbiomics and Immunology, Rheumatology and Infectious Diseases Research Area, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy
¹¹ Department of Translational Medicine and Surgery, Catholic University of the

Topic
IBD

Session
PP 05 IBD (Posters)

Conference
UEG Week 2023

Citation
United European Gastroenterology Journal 2023; 11 (Supplement 8)