GUSELKUMAB, AN IL-23P19 SUBUNIT–SPECIFIC MONOCLONAL ANTIBODY, BINDS CD64 ON THE SURFACE OF IL-23-SECRETING MYELOID CELLS, CAPTURES LOCALLY PRODUCED IL-23, AND DELIVERS IL-23 TO INTRACELLULAR COMPARTMENTS

Raja Atreya  ¹     Maria T. Abreu  ²     James G. Krueger  ³     Kilian Eyerich  ^{4, 5}     Robert Bissonnette  ⁶     Carrie Greving  ⁷     Brian Stoveken  ⁸     Deeper Hammaker  ⁸     Kristen Leppard  ⁸     John Hartman  ⁸     Indra Sarabia  ⁸     Matthew Duprie  ⁸     Joseph Brown  ⁸     M. Merle Elloso  ⁹     Phuc Bao  ⁹     Eilyn Lacy  ⁹     Kacey Sachen  ⁹     Christopher Ritchlin  ¹⁰     Iain B. McInnes  ¹¹     Matthieu Allez  ¹²     Anne Fourie  ^12    
1 Erlangen University Hospital, Erlangen, Germany
² University of Miami, Miami, FL, United States
³ The Rockefeller University, New York, NY, United States
⁴ Medical Center, Freiburg, Germany
⁵ Karolinska Institute, Stockholm, Sweden
⁶ Innovaderm Research Inc., Montréal, Québec, Canada
⁷ Janssen Research & Development, LLC, San Diego, CA, United States
⁸ Janssen Research & Development, LLC, Spring House, PA, United States
⁹ Janssen Scientific Affairs, LLC, Horsham, PA, United States
¹⁰ University of Rochester, Rochester, NY, United States
¹¹ University of Glasgow, Glasgow, United Kingdom
¹² Hôpital Saint-Louis, Université Paris Cité, Paris, France

Topic
IBD

Session
IL-23: Many but different? (Posters)

Conference
UEG Week 2023

Citation
United European Gastroenterology Journal 2023; 11 (Supplement 8)