Author

Kiichiro Tsuchiya 1

1 Advanced Therapeutics For Gastrointestinal Diseases, Tokyo Medical And Dental University, Tokyo, Japan

A NOVEL GENE TRANSDUCTION SYSTEM INTO SMALL INTESTINAL ORGANOID ENABLED THE IDENTIFICATION OF THE STEM CELL SUBPOPULATIONS IN A CRYPT.

Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Shuji Hibiya, Mamoru Watanabe

COMPLETE CONVERSION OF CRYPT PROGENITOR CELLS INTO ATOH1-POSITIVE CELLS BY TARGETED DELETION OF DLL1 AND DLL4 IN LGR5-POSITIVE INTESTINAL STEM CELLS.

Hiromichi Shimizu, Ryuichi Okamoto, Toru Nakata, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Mamoru Watanabe

CONSTRUCTION OF IN VITRO MODEL OF ULCERATIVE COLITIS USING MOUSE PRIMARY COLONIC ORGANOID

Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe

CONTIUOUS STIMULATION WITH CYTOKINES LEADS TO IRREVERSIBLE ACTIVATION OF NF-ΚB SIGNALING IN COLONIC EPITHELIAL CELLS BY ORGANOID CULTURE

Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe

ECTOPIC EXPRESSION OF REG3A IN THE MICE DISTAL COLON IS MEDIATED BY INTERACTIONS BETWEEN NOTCH AND IL-22 SIGNALING PATHWAYS, AND PROMOTES TISSUE REPAIR BY THE AUGMENTATION OF EGFR SIGNALING

Fumiaki Ishibashi, Konomi Kuwabara, Ami Kawamoto, Sho Anzai, Junichi Takahashi, Sayaka Nagata, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto

Establishment of chronic inflammation model using human small intestinal and colonic organoids

Shuji Hibiya, Kiichiro Tsuchiya, Nobuhiro Katsukura, Tomoaki Shirasaki, Sho Watanabe, Ryu Nishimura, Ryuichi Okamoto, Mamoru Watanabe

HUMAN ALPHA-DEFENSIN 6 REGULATED BY BOTH ATOH1 AND BETA-CATENIN MIGHT BE THE PATHOGENESIS OF CROHN’S DISEASE

Ryohei Hayashi, Kiichiro Tsuchiya, Shuji Hibiya, Nobukatsu Horita, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Mamoru Watanabe

IL-22-MEDIATED ANTIMICROBIAL RESPONSE IS REGULATED BY HES1 VIA STAT3-DEPENDENT TRANSCRIPTION IN HUMAN INTESTINAL EPITHELIAL CELLS

Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Mamoru Watanabe

LESION-SPECIFIC GENE EXPRESSION IN THE EPITHELIAL CELLS OF CROHN'S DISEASE BY COMPARING SMALL INTESTINAL ORGANOIDS FROM ACTIVE AND INACTIVE LESION IN THE SAME PATIENT

Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe

LINEAGE-SPECIFIC EXPRESSION OF BESTROPHIN-2 AND BESTROPHIN-4 IS REGULATED BY NOTCH SIGNALING IN HUMAN INTESTINAL EPITHELIAL CELLS.

Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Mamoru Watanabe

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