Author

Immaculada Silos-Santiago 1

1 Ironwood Pharmaceuticals, Inc

ACTIVATION OF THE GUANYLATE CYCLASE-C/CGMP PATHWAY DECREASES GASTROINTESTINAL PAIN

Immaculada Silos-Santiago, Hong Jin, Marco Kessler, Mark G. Currie, Gerhard Hannig, Ashley Blackshaw, Caroline B. Kurtz, Mark G. Currie, Stuart M. Brierley

CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED LONG-TERM BLADDER AFFERENT HYPERACTIVITY

Luke Grundy, Sonia Garcia-Caraballo, Jessica Maddern, Grigori Rychkov, Gerhard Hannig, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

DIFFERENT SUBTYPES OF PATIENTS WITH IRRITABLE BOWEL SYNDROME HAVE DISTINCT ALTERATIONS IN THE GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY

Andrea M. Harrington, Richard L. Young, Caroline B. Kurtz, Immaculada Silos-Santiago, Quoc Nam Nguyen, Jane Andrews, Stuart M. Brierley

EXTRACELLULAR CYCLIC GMP, THE DOWNSTREAM MEDIATOR RELEASED IN RESPONSE TO LINACLOTIDE-INDUCED ACTIVATION OF GUANYLATE CYCLASE C, REDUCES EXCITABILITY OF MURINE AND HUMAN DORSAL ROOT GANGLION NEURONS

Andrea Ghetti, Andrea M. Harrington, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

GUANYLATE CYCLASE-C EXPRESSION IS DOWN-REGULATED IN COLONIC BIOPSIES FROM FEMALE IRRITABLE BOWEL SYNDROME PATIENTS WITH CONSTIPATION

Sonia Garcia-Caraballo, Andrea M. Harrington, Joel Castro, Gerhard Hannig, Caroline B. Kurtz, Immaculada Silos-Santiago, Lin Chang, Stuart M. Brierley

HOW DOES PSYLLIUM REALLY WORK IN CONSTIPATION? A DOUBLE-BLIND CROSSOVER STUDY TO EVALUATE ITS IMPACT ON MAGNETIC RESONANCE IMAGING BIOMARKERS

Kathryn Murray, Giles Major, Caroline L. Hoad, Adam Nowak, Luca Marciani, Immaculada Silos-Santiago, Carolline Kurtz, Jeffrey Johnston, Penny A. Gowland, Robin Spiller

LINACLOTIDE INDUCES SECRETION OF CGMP FROM MOUSE COLONIC EPITHELIUM

Gerhard Hannig, Boris Tchernychev, Sarah Jacobson, Mark G. Currie, Immaculada Silos-Santiago, Caroline B. Kurtz, Mark G. Currie

LINACLOTIDE INDUCES SECRETION OF CYCLIC GMP INTO THE COLONIC SUBMUCOSAL LAYER: AN IN VIVO MICRODIALYSIS STUDY IN RATS

Jenny V Tobin, Sara Thomas, Robert Solinga, Jaime Masferrer, Craig Lunte, Gerhard Hannig, Immaculada Silos-Santiago

LINACLOTIDE-INDUCED CHRONIC ACTIVATION OF THE GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY INHIBITS ASCENDING NOCICEPTIVE PATHWAYS AND RESTORES ABERRANT SPINAL CORD SIGNALLING

Joel Castro, Andrea M. Harrington, Sonia Garcia-Caraballo, Jessica Maddern, Tracey O’Donnell, Luke Grundy, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

MODULATION OF MUCOSAL SENSITIVITY VIA THE EPITHELIAL GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY: LINACLOTIDE AS A REGULATOR OF VISCERAL SENSATION

Andrea M. Harrington, Joel Castro, Sonia Garcia-Caraballo, Jessica Maddern, Tracey O’Donnell, Luke Grundy, Grigori Rychkov, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

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