Author

Immaculada Silos-Santiago 1

1 Ironwood Pharmaceuticals, Inc

DIFFERENT SUBTYPES OF PATIENTS WITH IRRITABLE BOWEL SYNDROME HAVE DISTINCT ALTERATIONS IN THE GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY

Andrea M. Harrington, Richard L. Young, Caroline B. Kurtz, Immaculada Silos-Santiago, Quoc Nam Nguyen, Jane Andrews, Stuart M. Brierley

CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED LONG-TERM BLADDER AFFERENT HYPERACTIVITY

Luke Grundy, Sonia Garcia-Caraballo, Jessica Maddern, Grigori Rychkov, Gerhard Hannig, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

HOW DOES PSYLLIUM REALLY WORK IN CONSTIPATION? A DOUBLE-BLIND CROSSOVER STUDY TO EVALUATE ITS IMPACT ON MAGNETIC RESONANCE IMAGING BIOMARKERS

Kathryn Murray, Giles Major, Caroline L. Hoad, Adam Nowak, Luca Marciani, Immaculada Silos-Santiago, Carolline Kurtz, Jeffrey Johnston, Penny A. Gowland, Robin Spiller

LINACLOTIDE INDUCES SECRETION OF CGMP FROM MOUSE COLONIC EPITHELIUM

Gerhard Hannig, Boris Tchernychev, Sarah Jacobson, Mark G. Currie, Immaculada Silos-Santiago, Caroline B. Kurtz, Mark G. Currie

GUANYLATE CYCLASE-C EXPRESSION IS DOWN-REGULATED IN COLONIC BIOPSIES FROM FEMALE IRRITABLE BOWEL SYNDROME PATIENTS WITH CONSTIPATION

Sonia Garcia-Caraballo, Andrea M. Harrington, Joel Castro, Gerhard Hannig, Caroline B. Kurtz, Immaculada Silos-Santiago, Lin Chang, Stuart M. Brierley

ACTIVATION OF THE GUANYLATE CYCLASE-C/CGMP PATHWAY DECREASES GASTROINTESTINAL PAIN

Immaculada Silos-Santiago, Hong Jin, Marco Kessler, Mark G. Currie, Gerhard Hannig, Ashley Blackshaw, Caroline B. Kurtz, Mark G. Currie, Stuart M. Brierley

EXTRACELLULAR CYCLIC GMP, THE DOWNSTREAM MEDIATOR RELEASED IN RESPONSE TO LINACLOTIDE-INDUCED ACTIVATION OF GUANYLATE CYCLASE C, REDUCES EXCITABILITY OF MURINE AND HUMAN DORSAL ROOT GANGLION NEURONS

Andrea Ghetti, Andrea M. Harrington, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

LINACLOTIDE-INDUCED CHRONIC ACTIVATION OF THE GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY INHIBITS ASCENDING NOCICEPTIVE PATHWAYS AND RESTORES ABERRANT SPINAL CORD SIGNALLING

Joel Castro, Andrea M. Harrington, Sonia Garcia-Caraballo, Jessica Maddern, Tracey O’Donnell, Luke Grundy, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

LINACLOTIDE INDUCES SECRETION OF CYCLIC GMP INTO THE COLONIC SUBMUCOSAL LAYER: AN IN VIVO MICRODIALYSIS STUDY IN RATS

Jenny V Tobin, Sara Thomas, Robert Solinga, Jaime Masferrer, Craig Lunte, Gerhard Hannig, Immaculada Silos-Santiago

MODULATION OF MUCOSAL SENSITIVITY VIA THE EPITHELIAL GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY: LINACLOTIDE AS A REGULATOR OF VISCERAL SENSATION

Andrea M. Harrington, Joel Castro, Sonia Garcia-Caraballo, Jessica Maddern, Tracey O’Donnell, Luke Grundy, Grigori Rychkov, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

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