Author

Caroline B. Kurtz 1

1 Ironwood Pharmaceuticals, Inc

DIFFERENT SUBTYPES OF PATIENTS WITH IRRITABLE BOWEL SYNDROME HAVE DISTINCT ALTERATIONS IN THE GUANYLATE CYCLASE-C/CYCLIC GMP PATHWAY

Andrea M. Harrington, Richard L. Young, Caroline B. Kurtz, Immaculada Silos-Santiago, Quoc Nam Nguyen, Jane Andrews, Stuart M. Brierley

CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED LONG-TERM BLADDER AFFERENT HYPERACTIVITY

Luke Grundy, Sonia Garcia-Caraballo, Jessica Maddern, Grigori Rychkov, Gerhard Hannig, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

LINACLOTIDE INDUCES SECRETION OF CGMP FROM MOUSE COLONIC EPITHELIUM

Gerhard Hannig, Boris Tchernychev, Sarah Jacobson, Mark G. Currie, Immaculada Silos-Santiago, Caroline B. Kurtz, Mark G. Currie

GUANYLATE CYCLASE-C EXPRESSION IS DOWN-REGULATED IN COLONIC BIOPSIES FROM FEMALE IRRITABLE BOWEL SYNDROME PATIENTS WITH CONSTIPATION

Sonia Garcia-Caraballo, Andrea M. Harrington, Joel Castro, Gerhard Hannig, Caroline B. Kurtz, Immaculada Silos-Santiago, Lin Chang, Stuart M. Brierley

ASSESSING ADEQUATE RELIEF-BASED THRESHOLDS FOR ABDOMINAL AND BOWEL SYMPTOMS IN TWO PHASE 3 TRIALS OF LINACLOTIDE FOR IRRITABLE BOWEL SYNDROME WITH CONSTIPATION

Anthony J. Lembo, Bernard Lavins, Steven Shiff, Xinwei Jia, Mark G. Currie, James MacDougall, Steven Shiff, Mark G. Currie, Caroline B. Kurtz, Jeffrey Johnston

ACTIVATION OF THE GUANYLATE CYCLASE-C/CGMP PATHWAY DECREASES GASTROINTESTINAL PAIN

Immaculada Silos-Santiago, Hong Jin, Marco Kessler, Mark G. Currie, Gerhard Hannig, Ashley Blackshaw, Caroline B. Kurtz, Mark G. Currie, Stuart M. Brierley

EXTRACELLULAR CYCLIC GMP, THE DOWNSTREAM MEDIATOR RELEASED IN RESPONSE TO LINACLOTIDE-INDUCED ACTIVATION OF GUANYLATE CYCLASE C, REDUCES EXCITABILITY OF MURINE AND HUMAN DORSAL ROOT GANGLION NEURONS

Andrea Ghetti, Andrea M. Harrington, Caroline B. Kurtz, Immaculada Silos-Santiago, Stuart M. Brierley

DIFFERENTIAL EFFECTS OF EXTRACELLULAR CYCLIC GMP (CGMP) AND THE GUANYLATE CYCLASE-C (GC-C) AGONIST, LINACLOTIDE, ON MOUSE GASTRIC VAGAL AFFERENT MECHANOSENSITIVITY

Stephen Kentish, Tracey O'Donnell, Stuart M. Brierley, Caroline B. Kurtz, Amanda Page

BLOATING IN IRRITABLE BOWEL SYNDROME WITH CONSTIPATION: BASELINE SEVERITY AND RESPONSE TO TREATMENT IN 2 PHASE 3 TRIALS OF LINACLOTIDE

Brian Lacy, Bernard Lavins, James MacDougall, Rick Blakesley, Xinwei Jia, Caroline B. Kurtz, Jeffrey Johnston

IS RESPONSE TO LINACLOTIDE AFTER 4 WEEKS OF TREATMENT PREDICTIVE OF 12-WEEK IMPROVEMENT?

William D. Chey, Bernard Lavins, Steven Shiff, Mark G. Currie, Steven Shiff, James MacDougall, Caroline B. Kurtz, Mark G. Currie, Jeffrey Johnston

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